ALLTOX provides state-of-the-art testing on the prediction of allergic sensitisation within the frame of current European regulatory directives.
ALLTOX’s unique expertise in in vitro testing allows us to investigate the sensitization potential of all finished cosmetic and toiletry products. This is a strong advantage over the currently approved tests, which can be applied only to individual ingredients.
ALLTOX also provides the only test which is validated by European Authorities (ECVAM,European Centre for the Validation of Alternative Methods) to predict the sensitizing potential of chemicals, i.e., the Local Lymph Node Assay (LLNA: LLNA OFFICIAL JOURNAL)
The LLNA is an in vivo test. However, it implies a much reduced animal use and sufferings, as compared to the traditional guinea pig tests. The LLNA is a quantitative test which not only provides a “yes or no” type of answer, but also establish the sensitizing potential of chemicals. The usage of the LLNA is strongly supported by the EC ReACH directive .
ALLTOX is the joint venture between Abich, a company involved in analytical in vitro testing with special focus on biosafety issues, and the Laboratory of Cellular and Molecular Allergology of the Department of Biological and Technological Research at the San Raffaele Biomedical Science Park.
Abich provides a long-lasting expertise on biological and regulatory issues about biomedical and cosmetic products whereas the Laboratory of Cellular and Molecular Allergology has a documented experience on the cellular and molecular mechanisms of the generation of the allergic reaction in human experimental models. Several papers on peer-reviewed scientific international Journals have been generated by this synergy in collaboration with ECVAM (see references).