The skin absorption test allows you to evaluate the percutaneous absorption of specific chemicals and active ingredients, administered alone or in combination with other ingredients.
The test is performed on reconstructed human skin, on which the product is applied in a suitable vehicle.
At different times the proportion of active ingredient that is permeated through the skin in controlled conditions is measured, in parallel with the proportion that has remained on the skin. This allows building an absorption curve, which is predictive of in vivo conditions
The knowledge of the kinetics of percutaneous absorption of a substance for topical use, allows you to better assess the toxicological risk ad the risk to generate allergies. In fact, in the absence of percutaneous absorption, the lack of contact with the immune system prevents any possible sensitization