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  • ALLTOX
    • WHO WE ARE
    • AIMS
    • BACKGROUND
  • OUR SERVICES
    • IN VITRO SENSITIZATION ASSAYS
    • CYTOKINE RELEASE
    • SKIN ABSORPTION
    • NICKEL RELEASE
    • LLNA
    • LATEX ALLERGY
    • IN VITRO INHIBITION OF BASOPHIL DEGRANULATION
    • IN VITRO INHIBITION OF ALLERGIC SENSITIZATION
    • ATOPIC DERMATITIS
    • EXPERT REPORT AND ETHICAL CLEARANCE
    • HISTAMINE INTOLERANCE
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Who we are

ALLTOX provides state-of-the-art testing on the prediction of allergic sensitisation within the frame of current European regulatory directives.
ALLTOX's unique expertise in in vitro testing allows us to investigate the sensitization potential of all finished cosmetic and toiletry products. This is a strong advantage over the currently approved tests, which can be applied only to individual ingredients.
ALLTOX also provides the only test which is validated by European Authorities  (ECVAM,European Centre for the Validation of Alternative Methods) to predict the sensitizing potential of chemicals, i.e., the Local Lymph Node Assay (LLNA: LLNA OFFICIAL JOURNAL)

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Services

  • In vitro sensitization assays
  • Cytokine release
  • Skin absorption
  • Nickel release
  • LLNA
  • Latex allergy
  • In vitro inhibition of basophil degranulation
  • In vitro inhibition of allergic sensitization
  • Atopic dermatitis
  • Expert report and ethical clearance
  • Histamine intolerance

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News history

  • APRIL 2020

    ALLTOX funded research is published "The allergen Mus m 1.0102: Cysteine residues and molecular allergology" and "Thermal stability, ligand binding and allergenicity data of Mus m 1.0102 allergen and its cysteine mutants". The mutant C138A of major mouse allergen Mus m 1 is described, which is characterized by higher structural stability and lower tendency to aggregation

    Data Brief. 2020 Apr; 29: 105355, doi: 10.1016/j.dib.2020.105355
    Mol Immunol. 2020 Apr;120:1-12. doi: 10.1016/j.molimm.2020.01.022

  • AUGUST 2018

    ALLTOX funded research is published: "Multiple Epitope Presentation and Surface Density Control Enabled by Chemoselective Immobilization Lead to Enhanced Performance in IgE-binding Fingerprinting on Peptide Microarrays". Tandem peptide technology provides an approximately twofold increased IgE binding capacity with respect to the linear and branched peptides, in the context of a Multiple Epitope Presentation (MPE) setting

    Anal Chim Acta. 2017 Aug 29;983:189-197. doi: 10.1016/j.aca.2017.06.027

  • AUGUST 2017

    ALLTOX funded research is published: "Identification by Serological Proteome Analysis of Paramyosin as Prominent Allergen in Dust Mite Allergy". The relevance of Der p 11 in house dust might diagnosis is brought to the spotlight

    J Proteomics 2017 Aug 23;166:19-26. doi: 10.1016/j.jprot.2017.06.024

  • APRIL 2016

    ALLTOX SRL is funded by the EC Instrument: SMEInst-05-2016-2017: "Supporting innovative SMEs in the healthcare biotechnology sector" (Cell Technologies in Medical Applications)
    The grant will be used for the development of the MYA platform (Map Your Allergies): An innovative diagnostics platform for full mapping of personal allergies

  • MARCH 2016

    ALLTOX funded research is published:  "Serum diamine oxidase activity in patients with histamine intolerance ".
    The clinical application of the serum diamine oxidase measurement in patients with histamine intolerance is extensively characterized Int J Pharmacol Immunopathol. 2016; 29 (1): 105-11

  • JANUARY 2014

    ALLTOX funded research is published:  “Timothy-grass manganese superoxide dismutase identified BY proteomic: a new candidate grass allergen",  where a new grass allergen is described Ann Allergy Asthma Immunol. 2014 Mar;112(3):261

  • MAY 2012

    ALLTOX presents Discover Your Allergies at Fondazione Filarete Filarete Healthy Startups. Viale Ortles 22/4 - 20139 Milano

  • APRIL 2012

    SOLE 24ORE about ALLTOX  (SOLE)

  • MAY 2011

    ALLTOX joins ITALIACAMP MILANO 2011 with the DYA project: Discover your allergies

  • APRIL 2010

    LAUNCH OF THE DYA PROJECT AT BIOINITALY ALLTOX launches Discover Your Allergies (DYA),  a diagnostic tool allowing customers to exaustively define form a drop of blood all major allergies. An allergen micro-array based technology is used, which was developed in collaboration with C.N.R. (Milano)



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Alltox
- In vitro determination of allergenicity of xenobiotics 
- All-in-one molecular diagnosis of allergies 
- Histamine intolerance

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